Nattokinase: A Natural Way to Support Healthy Blood Pressure and Heart Health
- Nikki Griffith

- Jul 6
- 3 min read
If you've been looking for a natural way to support healthy blood pressure and better circulation, you may have come across a supplement called nattokinase. While it may not be as well known as fish oil or magnesium, nattokinase has been gaining attention because of its potential benefits for heart and blood vessel health.
At Optimal Health & Vitality, we believe in using science-backed nutrition and supplements alongside exercise, quality sleep, and healthy eating to help our clients live longer, healthier lives. Nattokinase is one supplement that may fit into that plan for the right person.
What Is Nattokinase?
Nattokinase is a serine protease enzyme isolated from natto, a traditional Japanese food made from fermented soybeans. Dr. Hiroyuki Sumi discovered it in 1980 while screening clot-degrading compounds. Unlike most cardiovascular supplements that work upstream by improving vessel dilation or reducing inflammation, nattokinase works downstream through a process called fibrinolysis. It breaks down fibrin, the protein mesh that holds blood clots together. It also appears to inactivate plasminogen activator inhibitor-1 (PAI-1), the body’s own brake on clot dissolution.
How Does Nattokinase Work?
To understand nattokinase, it helps to know about fibrin. Fibrin is a protein your body makes to help stop bleeding after an injury. Think of it as your body's natural "patch kit." When you get a cut, fibrin forms a strong net that helps create a blood clot. Once the injury heals, your body normally breaks down the extra fibrin so blood can flow freely again.
As we get older—or if we have high blood pressure, diabetes, chronic inflammation, or are less active—our bodies may not clear away fibrin as efficiently. Nattokinase appears to support your body's natural ability to maintain healthy fibrin balance, which may help support healthy circulation.
Can Nattokinase Help Lower Blood Pressure?
Research suggests it can. Several human studies have found that people taking nattokinase experienced modest reductions in blood pressure after about 8 weeks.
Nattokinase may be a helpful part of a complete health program that also includes:
Regular exercise
A healthy diet
Weight management
Good sleep
Stress reduction
Even small improvements in blood pressure can reduce the risk of heart disease and stroke over time.
Other Potential Benefits
Research suggests nattokinase may help support:
Healthy blood pressure
Healthy circulation
Normal blood flow
Healthy blood vessel function
Normal fibrin balance
Long-term cardiovascular wellness
Scientists continue to study its possible role in supporting healthy arteries and reducing cardiovascular risk factors.
Is Nattokinase a Blood Thinner?
This is one of the biggest misconceptions. Nattokinase does not work the same way as prescription blood thinners like warfarin or Eliquis. Instead, it appears to support your body's natural process of breaking down excess fibrin and maintaining healthy circulation. However, because it may affect blood clotting, anyone taking prescription blood thinners or antiplatelet medications should speak with their healthcare provider before using nattokinase.
Who May Benefit?
Nattokinase may be worth discussing with your healthcare provider if you:
Have elevated blood pressure
Want to support heart health naturally
Have a family history of cardiovascular disease
Are over age 50
Want to improve overall circulation
Are focused on healthy aging
Our Recommended Dose
At Optimal Health & Vitality, we commonly recommend: Nattokinase
4,000 FU (200 mg) daily
Take on an empty stomach
Either first thing in the morning or before bed
Who Should NOT Take Nattokinase?
Nattokinase is not appropriate for everyone. Talk with your healthcare provider before taking it if you:
Take prescription blood thinners
Take antiplatelet medications
Have a bleeding disorder
Are scheduled for surgery
Are pregnant or breastfeeding
The Bottom Line
There is no magic pill for heart health. The biggest improvements still come from eating well, building muscle, staying active, sleeping well, and maintaining a healthy body weight. But when used as part of a complete health plan, nattokinase may be another valuable tool to support healthy blood pressure, better circulation, and long-term cardiovascular wellness.
At Optimal Health & Vitality, we don't believe in simply treating symptoms. We believe in helping people optimize their health from the inside out by combining evidence-based nutrition, exercise, lifestyle changes, and carefully selected supplements that support the body's natural ability to thrive.
Coach Nikki's Pro Tip:
"Supplements work best when they support healthy habits, not replace them. Nattokinase is one more tool that may help your heart and circulation, but lasting health always starts with nutrition, strength training, quality sleep, and consistency."





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